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Differential influence of molybdenum disulfide at the nanometer and micron scales in the intestinal metabolome and microbiome of mice

Abstract

Molybdenum disulfide nanomaterial (nano-MoS2) is receiving increasing amounts of attention due to its special physicochemical characteristics. However, little is known about influence of the different sizes of MoS2 on the intestinal metabolome and microbiome. In this study, C57BL/6 mice were exposed to nano-MoS2 and MoS2 micromaterial (micro-MoS2) via food premixed with 15 and 150 mg MoS2/kg food for 90 days. The results showed that nano-MoS2 and micro-MoS2 exposure induced the Mo accumulation in mouse organs, especially in the small intestine (SI) and large intestine (LI). Nano-MoS2 had a higher bioavailability and intestinal inflammation than micro-MoS2. Metabolome analyses showed that both types of MoS2 exposure changed the metabolic profiles of the intestine and intestinal microbiota. Ten and 8 significantly altered microbial-host cometabolites were found in the SI and LI, respectively, and were primarily involved in amino acid and carbohydrate metabolism. Additionally, both types of MoS2 exposure obviously changed the intestinal microbiota, especially in the LI. Correlation analysis suggest that micro-MoS2 could alter the intestinal metabolic profiles by changing the microbial community, but nano-MoS2 could cause the similar effects by changing the microbial community and direct intestine toxicity. This study provides insights into the toxicity and health risks of nano-MoS2 and micro-MoS2 introduced by oral exposure.

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Publication details

The article was received on 13 Sep 2018, accepted on 01 Apr 2019 and first published on 03 Apr 2019


Article type: Paper
DOI: 10.1039/C8EN01019F
Citation: Environ. Sci.: Nano, 2019, Accepted Manuscript

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    Differential influence of molybdenum disulfide at the nanometer and micron scales in the intestinal metabolome and microbiome of mice

    B. Wu, L. Chen, X. Wu, H. Hou, Z. Wang and S. Liu, Environ. Sci.: Nano, 2019, Accepted Manuscript , DOI: 10.1039/C8EN01019F

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