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Comment on “Isocyanic acid (HNCO) and its fate in the atmosphere: a review” by M. D. Leslie, M. Ridoli, J. G. Murphy and N. Borduas-Dedekind, Environ. Sci.: Processes Impacts, 2019, 21, 793

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Abstract

Can 1 ppb of isocyanic acid in air cause 100 μM in the blood stream? The impact of indoor and outdoor isocyanic acid (HNCO) levels may be of concern to human health. HNCO is well soluble in water but hydrolyzes rather slowly. Recently determined thermodynamic data and HNCO hydrolysis kinetics indicate that high blood levels might be reached. This data has been complemented with a brief assessment of kinetic information from the (bio)chemical and medical literature about carbamoylation reactions with proteins, indicating that other bodily elimination mechanisms cannot be ignored. Expected incremental blood levels corresponding to 1 ppbv HNCO in air are estimated to be in the low nM range. Acute toxic effects therefore seem unlikely, but chronic exposure to higher concentrations may still be of significance.

Graphical abstract: Comment on “Isocyanic acid (HNCO) and its fate in the atmosphere: a review” by M. D. Leslie, M. Ridoli, J. G. Murphy and N. Borduas-Dedekind, Environ. Sci.: Processes Impacts, 2019, 21, 793

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Publication details

The article was received on 04 Sep 2019, accepted on 30 Oct 2019 and first published on 08 Nov 2019


Article type: Comment
DOI: 10.1039/C9EM00403C
Environ. Sci.: Processes Impacts, 2019, Advance Article

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    Comment on “Isocyanic acid (HNCO) and its fate in the atmosphere: a review” by M. D. Leslie, M. Ridoli, J. G. Murphy and N. Borduas-Dedekind, Environ. Sci.: Processes Impacts, 2019, 21, 793

    P. M. Plehiers, Environ. Sci.: Processes Impacts, 2019, Advance Article , DOI: 10.1039/C9EM00403C

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