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Issue 4, 2019
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Effect of environmental factors on the oxidative transformation of cephalosporin antibiotics by manganese dioxides

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Abstract

This study aimed to explore the oxidation and transformation of the cephalosporins cefotaxime (CTX), cephalexin (CFX), cephradine (CFD), cephapirin (CFP) and cefazolin (CFZ) by δ-MnO2. The results showed that the MnO2 oxidation rate was promoted by environmental factors such as higher MnO2 loading, lower initial cephalosporin concentration and lower solution pH. The inhibitory effect occurred in the presence of dissolved organic matter and dissolved cations (inhibitory capacity: Mn2+ > Ca2+ > Mg2+ > Fe3+). Total organic carbon analysis indicated that the transformation byproducts of the cephalosporins are less reactive and persistent under MnO2 oxidation. Twelve transformation byproducts (9 CFP byproducts and 3 CTX byproducts) were identified, and two oxidative transformation pathways were proposed: one occurred in the cephem for CFP, and the other occurred at the substituent at the amine position for CTX. The effect of solar light on the oxidation of the five cephalosporin antibiotics by δ-MnO2 was also investigated, and the results indicated that the initial dissolution rate of δ-MnO2 under sunlight was approximately eight times faster than that in the dark in the presence of CFP.

Graphical abstract: Effect of environmental factors on the oxidative transformation of cephalosporin antibiotics by manganese dioxides

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Publication details

The article was received on 06 Dec 2018, accepted on 13 Feb 2019 and first published on 14 Feb 2019


Article type: Paper
DOI: 10.1039/C8EM00562A
Citation: Environ. Sci.: Processes Impacts, 2019,21, 692-700

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    Effect of environmental factors on the oxidative transformation of cephalosporin antibiotics by manganese dioxides

    M. Hsu, T. Kuo, W. Wei-Po Lai, C. Huang, C. Hsu, Y. Chen and A. Y. Lin, Environ. Sci.: Processes Impacts, 2019, 21, 692
    DOI: 10.1039/C8EM00562A

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