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Issue 45, 2019
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A small-sized and stable 2D metal–organic framework: a functional nanoplatform for effective photodynamic therapy

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Abstract

The efficiency of photosensitizers in tumor photodynamic therapy (PDT) often compromises their poor water solubility, low extinction coefficients, photobleaching, and dissatisfactory reactive oxygen species (ROS) generation efficiency. Herein, a nanoscale 2D metal–organic framework, Sm-H2TCPP nanosheets, was first synthesized by Sm3+-driven coordination with a porphyrin derivative (tetrakis(4-carboxyphenyl)porphyrin (H2TCPP)) for highly effective PDT of breast cancer. The prepared Sm-H2TCPP possessed nanoplate morphology with ultrathin thickness at the sub-10 nm level and an ultrasmall plane size at the sub-100 nm level. Compared with free H2TCPP, the prominent ROS generation capacity of the well-defined Sm-H2TCPP nanosheets is mainly attributed to their improved physicochemical properties and the enhanced intersystem crossing caused by heavy Sm nodes. The significantly improved PDT efficacy of the Sm-H2TCPP nanosheets was further investigated in vitro and in vivo based on the MCF-7 breast cancer model. It is envisaged that the Sm-H2TCPP nanosheets will offer a new avenue for the development of a new class of potential PDT agents.

Graphical abstract: A small-sized and stable 2D metal–organic framework: a functional nanoplatform for effective photodynamic therapy

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Publication details

The article was received on 17 Sep 2019, accepted on 25 Oct 2019 and first published on 28 Oct 2019


Article type: Communication
DOI: 10.1039/C9DT03706C
Dalton Trans., 2019,48, 16861-16868

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    A small-sized and stable 2D metal–organic framework: a functional nanoplatform for effective photodynamic therapy

    Z. Gao, F. Chen, Y. Li, Y. Zhang, K. Cheng, P. An and B. Sun, Dalton Trans., 2019, 48, 16861
    DOI: 10.1039/C9DT03706C

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