Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 44, 2019
Previous Article Next Article

2,4-Substituted bispidines as rigid hosts for versatile applications: from κ-opioid receptor to metal coordination

Author affiliations

Abstract

Bispidones (3,7-diazabicyclo[3.3.1]nonan-9-one) are bicyclic analogues of the natural antiarrhythmic agent, spartein. They can straightforwardly be obtained from two successive Mannich reactions. Reduction of the ketone gives the corresponding bispidol. Substituted bispidones and bispidols offer a large playground by varying the substituents, the configuration of the carbon atoms in position 2 and 4 as well as the conformation of the bicycle. While chair–boat conformers display a strong affinity for κ-opioid receptors, chair–chair bispidines provide adaptable coordination spheres for transition metal and rare-earth ions. Because of their very rich coordination chemistry, substituted bispidines have emerged in various applications of coordination chemistry, such as catalysis, magnetism and medical imaging.

Graphical abstract: 2,4-Substituted bispidines as rigid hosts for versatile applications: from κ-opioid receptor to metal coordination

Back to tab navigation

Article information


Submitted
27 Aug 2019
Accepted
04 Oct 2019
First published
04 Oct 2019

Dalton Trans., 2019,48, 16476-16492
Article type
Perspective

2,4-Substituted bispidines as rigid hosts for versatile applications: from κ-opioid receptor to metal coordination

A. M. Nonat, A. Roux, M. Sy and L. J. Charbonnière, Dalton Trans., 2019, 48, 16476
DOI: 10.1039/C9DT03480C

Social activity

Search articles by author

Spotlight

Advertisements