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Issue 40, 2019
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Three peroxidovanadium(v) compounds mediated by transition metal cations for enhanced anticancer activity

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Abstract

Three peroxidovanadium(V) compounds with different ligands (L1–L3) {L1 = N-tris(hydroxymethyl)methylglycine; L2 = ethylenediamine-N,N′-diacetic acid; L3 = 2,2-[(2-amino-2-oxoethyl)imino]diacetic acid} were first synthesized, characterized and further investigated for their anticancer activities under the mediation of transition metal cations. Encouragingly, all compounds showed preferentially enhanced cytotoxicity toward cancer cells (MCF-7 and A549) compared to normal cells (BEAS-2B) under the mediation of transition metal cations (Mn2+ or Fe2+), especially for Mn2+. It was noted that cell death was triggered by the transition metal cation-mediated peroxidovanadium(V) compounds through the induction of early apoptosis, inhibition of cell cycles, and boosting the generation of intracellular reactive oxygen species (ROS). Mechanistic studies further elucidated the vital roles of an acidic environment and transition metal cations for the anticancer activity of peroxidovanadium(V) compounds. Therefore, this study will offer precious insight into the development of the transition metal cation-mediated peroxidovanadium(V) compounds for further clinical translation.

Graphical abstract: Three peroxidovanadium(v) compounds mediated by transition metal cations for enhanced anticancer activity

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Publication details

The article was received on 19 Aug 2019, accepted on 17 Sep 2019 and first published on 17 Sep 2019


Article type: Paper
DOI: 10.1039/C9DT03378E
Dalton Trans., 2019,48, 15160-15169

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    Three peroxidovanadium(V) compounds mediated by transition metal cations for enhanced anticancer activity

    F. Chen, Z. Gao, C. You, H. Wu, Y. Li, X. He, Y. Zhang, Y. Zhang and B. Sun, Dalton Trans., 2019, 48, 15160
    DOI: 10.1039/C9DT03378E

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