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Issue 40, 2019
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Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts

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Abstract

Signal Amplification By Reversible Exchange (SABRE) is a hyperpolarisation technique that commonly uses [Ir(H)2(carbene)(substrate)3]Cl complexes to catalytically transfer magnetisation from para-hydrogen derived hydride ligands to coordinated substrates. Here, we explore the reactivity of a novel class of such catalysts based on sulfoxide containing [IrCl(H)2(carbene)(DMSO)2], which are involved in the hyperpolarisation of pyruvate using SABRE. We probe the reactivity of this species by NMR and DFT and upon reaction with sodium pyruvate establish the formation of two isomers of [Ir(H)22-pyruvate)(DMSO)(IMes)]. Studies with related disodium oxalate yield [Ir2(H)4(IMes)2(DMSO)222-Oxalate)] that is characterised by NMR and X-ray diffraction.

Graphical abstract: Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts

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Publication details

The article was received on 18 Jul 2019, accepted on 06 Sep 2019 and first published on 24 Sep 2019


Article type: Paper
DOI: 10.1039/C9DT02951F
Dalton Trans., 2019,48, 15198-15206
  • Open access: Creative Commons BY license
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    Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts

    Ben. J. Tickner, J. S. Lewis, R. O. John, A. C. Whitwood and S. B. Duckett, Dalton Trans., 2019, 48, 15198
    DOI: 10.1039/C9DT02951F

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