Reversible turn-on fluorescent sensors of Cu(II) are of high interest for biological studies. We re-investigate a reported sensor, showing that turn-on occurs via irreversible Cu(II)-induced sensor oxidation only in the presence of acetonitrile. This prevents its application in biological studies and highlights the challenge of establishing a reversible Cu(II) turn-on sensor.
E. Falcone, A. Sour, V. Lebrun, G. Ulrich, L. Raibaut and P. Faller, Dalton Trans., 2019, 48, 14233 DOI: 10.1039/C9DT02864A
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