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Issue 44, 2019
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Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

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Abstract

New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells.

Graphical abstract: Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

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Publication details

The article was received on 18 Jun 2019, accepted on 24 Sep 2019 and first published on 30 Oct 2019


Article type: Paper
DOI: 10.1039/C9DT02570G
Dalton Trans., 2019,48, 16509-16517
  • Open access: Creative Commons BY license
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    Palladium(II) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

    C. G. Oliveira, I. Romero-Canelón, M. M. Silva, J. P. C. Coverdale, P. I. S. Maia, A. A. Batista, S. Castelli, A. Desideri, P. J. Sadler and V. M. Deflon, Dalton Trans., 2019, 48, 16509
    DOI: 10.1039/C9DT02570G

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