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Two telomerase-targeting Pt(ii) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells

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Abstract

Two novel Pt(II) complexes, [Pt(B-TFA)Cl]Cl (Pt1) and [Pt(J-TFA)Cl]Cl (Pt2) with jatrorrhizine and berberine derivatives (B-TFA and J-TFA) were first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors, which can induce bladder T-24 tumor cell apoptosis by targeting telomerase, together with induction of mitochondrial dysfunction, telomere DNA damage and cell-cycle arrest. Importantly, T-24 tumor inhibition rate (TIR) was 50.4% for Pt2, which was higher than that of Pt1 (26.4%) and cisplatin (37.1%). Taken together, all the results indicated that jatrorrhizine and berberine derivatives Pt1 and Pt2 show low toxicity and could be novel Pt-based anti-cancer drug candidates.

Graphical abstract: Two telomerase-targeting Pt(ii) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells

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Publication details

The article was received on 05 Jun 2019, accepted on 24 Sep 2019 and first published on 25 Sep 2019


Article type: Paper
DOI: 10.1039/C9DT02381J
Dalton Trans., 2019, Advance Article

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    Two telomerase-targeting Pt(II) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells

    Q. Qin, Z. Wang, X. Huang, M. Tan, Z. Luo, S. Wang, B. Zou and H. Liang, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C9DT02381J

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