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Spiropyrans for light-controlled drug delivery

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Abstract

The supramolecular assembly of acetylsalicylic acid to a merocyanine–Zn complex translates into a photo-controllable drug delivery system. Herein, we present the synthesis and spectroscopic analysis of a three-component assembly combining a spiropyran derivative, a zinc(II) cation, and acetylsalicylic acid. The ON/OFF system can be modulated by safe and easily affordable stimuli, for the specific delivery of more than one active compound. Our results confirm the formation of a ternary system in solution, where the behaviour is dominated by photo-induced responses, and pave the way for the use of such smart platforms for medicinal chemistry purposes.

Graphical abstract: Spiropyrans for light-controlled drug delivery

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Publication details

The article was received on 17 May 2019, accepted on 09 Jul 2019 and first published on 10 Jul 2019


Article type: Paper
DOI: 10.1039/C9DT02092F
Dalton Trans., 2019, Advance Article

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    Spiropyrans for light-controlled drug delivery

    F. Cardano, E. Del Canto and S. Giordani, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C9DT02092F

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