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N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+

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Abstract

Two Rh(III) and Ir(III) half-sandwich quinoline-based complexes were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. These half-sandwich organometallic complexes can also facilitate transfer hydrogenation, by converting β-nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH) in the presence of sodium formate. Co-administration of the iridium(III) complex with sodium formate enhances the antiplasmodial activity in the chloroquine-resistant (K1) strain of Plasmodium falciparum, intimating that metal-mediated transfer hydrogenations can be achieved in malarial parasitic cells.

Graphical abstract: N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+

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Publication details

The article was received on 15 May 2019, accepted on 09 Aug 2019 and first published on 09 Aug 2019


Article type: Communication
DOI: 10.1039/C9DT02030F
Dalton Trans., 2019, Advance Article

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    N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+

    T. Stringer, D. R. Melis and G. S. Smith, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C9DT02030F

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