Jump to main content
Jump to site search

Issue 25, 2019
Previous Article Next Article

Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents

Author affiliations

Abstract

We reported a set of water-soluble transition metal complexes that can serve as both 19F and PARACEST magnetic resonance imaging agents. The high number of equivalent fluorine atoms and the paramagnetic effect of metals offer these complexes high 19F sensitivity as demonstrated by in vitro19F MRI experiments. The complexes contain carboxamide groups appended onto a cyclen macrocycle, which provide 1H CEST peaks well differentiated from bulk water. The Co(II) agent displays two CEST peaks that can be utilized for ratiometric pH determination and the concept of combining 19F MR and PARACEST as complementary imaging techniques was demonstrated with the Fe(II) complex.

Graphical abstract: Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 May 2019, accepted on 31 May 2019 and first published on 31 May 2019


Article type: Paper
DOI: 10.1039/C9DT01852B
Dalton Trans., 2019,48, 9337-9341

  •   Request permissions

    Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents

    M. Yu, B. S. Bouley, D. Xie and E. L. Que, Dalton Trans., 2019, 48, 9337
    DOI: 10.1039/C9DT01852B

Search articles by author

Spotlight

Advertisements