Jump to main content
Jump to site search


Endoplasmic reticulum targeted cyclometalated iridium(III) complexes as efficient photodynamic therapy photosensitizers

Author affiliations

Abstract

The endoplasmic reticulum (ER) is an indispensable organelle that undertakes the synthesis and export of proteins and membrane lipids. Subtle interferences of the ER redox signaling pathway are very likely to cause ER-stress induced apoptosis. In view of this, we herein present a series of ER-targeted Ir(III) complexes (Ir1–Ir3) as photodynamic therapy (PDT) photosensitizers with a gradually extended conjugation area in the main ligand, and study the correlation between the conjugation area and PDT performance. The results showed that all of these complexes can accumulate in the ER and effectively induce cell apoptosis after PDT therapeutics (405 nm, 6 J cm−2) by an ER stress mechanism, and both their singlet oxygen quantum yields and cytotoxicities increase as the conjugation area extends. All complexes showed PDT efficacy towards different cancer cell lines. Among them, Ir2 exhibited the highest PI value (94.3) against A549 cells with an IC50 down to 0.65 μM. In addition, the post PDT ER-stress induced apoptosis along with the efflux of Ca2+ from the ER system in A549 cells in a short period of time (45–90 min) with the pretreatment of Ir2 was demonstrated. All of these results indicate the promising potential of Ir2 as an effective PDT photosensitizer.

Graphical abstract: Endoplasmic reticulum targeted cyclometalated iridium(iii) complexes as efficient photodynamic therapy photosensitizers

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Mar 2019, accepted on 01 Apr 2019 and first published on 02 Apr 2019


Article type: Paper
DOI: 10.1039/C9DT01072F
Citation: Dalton Trans., 2019, Advance Article

  •   Request permissions

    Endoplasmic reticulum targeted cyclometalated iridium(III) complexes as efficient photodynamic therapy photosensitizers

    B. Yuan, J. Liu, R. Guan, C. Jin, L. Ji and H. Chao, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C9DT01072F

Search articles by author

Spotlight

Advertisements