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Zwitterionic and Cationic Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Bearing Sulfonate Groups: Synthesis, Characterization and Their Different Biological Activity

Abstract

Previous studies for the neutral and cationic half-sandwich iridium(III) and ruthenium(II) complexes displayed that the charge and substitution pattern of the bidentate ligands, as well as the nature of accompanying counteranion have a significant effect on their biologica activity. In this contribution, a series of zwitterionic and cationic half-sandwich iridium(III) and ruthenium(II) complexes containing sulfonate groups have been prepared and characterized. The different location of counteranions between these two kinds of complexes exerts great influence on cytotoxic activity towards cancer cells. The various possible mechanism of actions (MoAs) of the complexes was determined by flow cytometry. This work has shown for the first time the different biological activity between zwitterionic and cationic half-sandwich complexes.

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Publication details

The article was received on 19 Jan 2019, accepted on 07 Feb 2019 and first published on 08 Feb 2019


Article type: Communication
DOI: 10.1039/C9DT00259F
Citation: Dalton Trans., 2019, Accepted Manuscript

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    Zwitterionic and Cationic Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Bearing Sulfonate Groups: Synthesis, Characterization and Their Different Biological Activity

    Y. Yang, X. Ge, L. Guo, T. Zhu, Z. Tian, H. Zhang, Q. Du, H. Peng, W. Ma and Z. Liu, Dalton Trans., 2019, Accepted Manuscript , DOI: 10.1039/C9DT00259F

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