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Facile preparation of a Ca(II) carboxymethyl cellulose complex with enhanced calcium bioavailability for treatment of osteoporosis

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Abstract

At present, though calcium (Ca) reagents with high calcium contents are widely synthesized, their wide application is limited due to their low absorption rates and poor bioavailability. Here we use a carboxymethyl cellulose (CMC) derivative with high water solubility and biocompatibility as a ligand to bind Ca2+. The resulting CaCMC complex exhibits remarkable solubility and absorbability under both basic and acidic conditions as well as in stomach mimicking and the gastrointestinal tract. Importantly, this Ca reagent shows high in vivo calcium bioavailability. Data from osteoporosis mouse models show that the CaCMC complex is superior to calcium carbonate in the treatment of osteoporosis. Therefore, the resulting CaCMC complex is used as a new, highly effective and desirable Ca supplement for daily life and clinical applications.

Graphical abstract: Facile preparation of a Ca(ii) carboxymethyl cellulose complex with enhanced calcium bioavailability for treatment of osteoporosis

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Publication details

The article was received on 15 Jan 2019, accepted on 24 Mar 2019 and first published on 26 Mar 2019


Article type: Paper
DOI: 10.1039/C9DT00202B
Citation: Dalton Trans., 2019, Advance Article

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    Facile preparation of a Ca(II) carboxymethyl cellulose complex with enhanced calcium bioavailability for treatment of osteoporosis

    J. Hai, X. Tan, S. Yang, F. Chen, T. Li, X. Yang, Y. Zhu and B. Wang, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C9DT00202B

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