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Issue 8, 2019
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Facile Buchwald–Hartwig coupling of sterically encumbered substrates effected by PNP ligands

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Abstract

The diphosphinoamine ligands [(Ph2P)2N(Ar); 1 (Ar = C6H5), 2 (Ar = 2,6-iPr2C6H3)] were effectively utilized in Buchwald–Hartwig coupling of a range of sterically demanding substrates. The reaction was carried out using conventional and microwave routes and the latter reduces the reaction time from 3 d to 15–30 min. A broad substrate scope was achieved in this protocol and most of the coupling products are isolated on a mutligram scale. DFT calculations were carried out to elucidate the reaction mechanism.

Graphical abstract: Facile Buchwald–Hartwig coupling of sterically encumbered substrates effected by PNP ligands

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Publication details

The article was received on 12 Jan 2019, accepted on 24 Jan 2019 and first published on 25 Jan 2019


Article type: Paper
DOI: 10.1039/C9DT00159J
Citation: Dalton Trans., 2019,48, 2730-2734

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    Facile Buchwald–Hartwig coupling of sterically encumbered substrates effected by PNP ligands

    N. Kathewad, A. M. C., N. Parvin, S. Parambath, P. Parameswaran and S. Khan, Dalton Trans., 2019, 48, 2730
    DOI: 10.1039/C9DT00159J

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