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EDTA-Na3 functionalized Fe3O4 nanoparticles: grafting density control for MRSA eradication

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Abstract

We report a synthesis strategy to simplify often cumbersome post-synthesis ligand exchange protocols and use that approach to synthesize EDTA-Na3 (N-(trimethoxysilylpropyl)ethylenediaminetriacetate, trisodium salt) functionalized hydrophilic and biocompatible Fe3O4 nanoparticles. The grafting density of EDTA-Na3 has been controlled from 0.07–0.37 μmol m−2 by varying the time at which EDTA-Na3 was added to the reaction. The success of EDTA-Na3 surface functionalization has been verified using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and Mössbauer spectroscopy techniques. Mössbauer spectroscopy results showed the evidence of Fe-EDTA monomer and dimer formation signifying covalent bonding between Fe ions and EDTA-Na3. The earliest addition of EDTA-Na3 resulted in the most stable dispersion of nanoparticles in water and phosphate buffered saline (PBS) which remained stable for more than a month. In addition, our results suggest that these nanoparticles can have useful applications in magnetic hyperthermia and eradication of methicillin-resistant Staphylococcus aureus (MRSA) bacteria in presence of an ac magnetic field.

Graphical abstract: EDTA-Na3 functionalized Fe3O4 nanoparticles: grafting density control for MRSA eradication

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Publication details

The article was received on 29 Dec 2018, accepted on 16 Apr 2019 and first published on 16 Apr 2019


Article type: Paper
DOI: 10.1039/C8DT05152F
Citation: Dalton Trans., 2019, Advance Article

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    EDTA-Na3 functionalized Fe3O4 nanoparticles: grafting density control for MRSA eradication

    P. K. Manna, R. Nickel, J. Li, Y. Wroczynskyj, S. Liu and J. van Lierop, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C8DT05152F

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