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Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

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Abstract

Herein we report an efficient manganese-catalyzed C-alkylation of unactivated amides and tert-butyl acetate using alcohols as alkylating agents. This elegant approach exhibits a broad substrate scope providing the C–C coupled products of amides via a hydrogen auto-transfer strategy using aryl, heteroaryl, and aliphatic alcohols.

Graphical abstract: Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

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Publication details

The article was received on 20 Dec 2018, accepted on 12 Mar 2019 and first published on 20 Mar 2019


Article type: Communication
DOI: 10.1039/C8DT05020A
Citation: Dalton Trans., 2019, Advance Article

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    Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

    J. Rana, V. Gupta and E. Balaraman, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C8DT05020A

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