Jump to main content
Jump to site search


52g/55 Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

Author affiliations

Abstract

trans-1,2-Diaminocyclohexane-N,N,N′,N′-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.

Graphical abstract: 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

Back to tab navigation

Publication details

The article was received on 19 Dec 2018, accepted on 05 Feb 2019 and first published on 06 Feb 2019


Article type: Paper
DOI: 10.1039/C8DT04996C
Citation: Dalton Trans., 2019, Advance Article

  •   Request permissions

    52g/55 Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

    M. R. Brandt, C. Vanasschen, J. Ermert, H. H. Coenen and B. Neumaier, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C8DT04996C

Search articles by author

Spotlight

Advertisements