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Biophysical analysis of cancer stem cell-potent copper(II) coordination complexes

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Abstract

Copper(II) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(I) form and releasing the associated NSAIDs.

Graphical abstract: Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

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Publication details

The article was received on 28 Nov 2018, accepted on 02 Jan 2019 and first published on 02 Jan 2019


Article type: Communication
DOI: 10.1039/C8DT04706E
Citation: Dalton Trans., 2019, Advance Article

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    Biophysical analysis of cancer stem cell-potent copper(II) coordination complexes

    P. Zheng, A. Eskandari, C. Lu, K. Laws, L. Aldous and K. Suntharalingam, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C8DT04706E

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