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Issue 3, 2019
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Synthesis, characterization and biological investigation of platinum(ii) complexes with asparagusic acid derivatives as ligands

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Abstract

After more than 50 years of platinum-based anticancer research only three compounds are in clinical use worldwide. The use of the well-known lead compound of this class of anticancer agents, cisplatin, is limited by its side effects and varying resistance mechanisms. Therefore, we report on platinum(II) compounds with asparagusic acid derivatives as ligands which show interesting anticancer results on cisplatin resistant cell lines.

Graphical abstract: Synthesis, characterization and biological investigation of platinum(ii) complexes with asparagusic acid derivatives as ligands

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Supplementary files

Article information


Submitted
22 Jun 2018
Accepted
05 Dec 2018
First published
06 Dec 2018

Dalton Trans., 2019,48, 936-944
Article type
Paper

Synthesis, characterization and biological investigation of platinum(II) complexes with asparagusic acid derivatives as ligands

J. Hildebrandt, R. Trautwein, D. Kritsch, N. Häfner, H. Görls, M. Dürst, I. B. Runnebaum and W. Weigand, Dalton Trans., 2019, 48, 936 DOI: 10.1039/C8DT02553C

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