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Issue 3, 2019
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Synthesis, characterization and biological investigation of platinum(II) complexes with asparagusic acid derivatives as ligands

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Abstract

After more than 50 years of platinum-based anticancer research only three compounds are in clinical use worldwide. The use of the well-known lead compound of this class of anticancer agents, cisplatin, is limited by its side effects and varying resistance mechanisms. Therefore, we report on platinum(II) compounds with asparagusic acid derivatives as ligands which show interesting anticancer results on cisplatin resistant cell lines.

Graphical abstract: Synthesis, characterization and biological investigation of platinum(ii) complexes with asparagusic acid derivatives as ligands

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Publication details

The article was received on 22 Jun 2018, accepted on 05 Dec 2018 and first published on 06 Dec 2018


Article type: Paper
DOI: 10.1039/C8DT02553C
Dalton Trans., 2019,48, 936-944

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    Synthesis, characterization and biological investigation of platinum(II) complexes with asparagusic acid derivatives as ligands

    J. Hildebrandt, R. Trautwein, D. Kritsch, N. Häfner, H. Görls, M. Dürst, I. B. Runnebaum and W. Weigand, Dalton Trans., 2019, 48, 936
    DOI: 10.1039/C8DT02553C

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