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Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids

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Abstract

One of the key factors to construct a productive whole-cell biocatalytic cascade may include the design of the biotransformation pathways, discovery and engineering of the cascade enzymes, and functional and balanced expression of the cascade enzymes in microbial cells as well as systematic engineering of the whole-cell biocatalytic cascades. Such issues are covered in this review exemplified for the biotransformation of renewable fatty acids into industrially relevant oleochemicals (e.g., medium-chain fatty acids such as n-nonanoic acid, 9-hydroxynonanoic acid, 9-aminononanoic acid, and 1,9-nonanedioic acid) as model systems.

Graphical abstract: Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids

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Publication details

The article was received on 06 Sep 2019, accepted on 14 Nov 2019 and first published on 19 Nov 2019


Article type: Minireview
DOI: 10.1039/C9CY01802F
Catal. Sci. Technol., 2019, Advance Article

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    Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids

    J. Song, J. Seo, D. Oh, U. T. Bornscheuer and J. Park, Catal. Sci. Technol., 2019, Advance Article , DOI: 10.1039/C9CY01802F

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