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Issue 20, 2019
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Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

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Abstract

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.

Graphical abstract: Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

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Article information


Submitted
01 Aug 2019
Accepted
30 Aug 2019
First published
03 Sep 2019

This article is Open Access

Catal. Sci. Technol., 2019,9, 5487-5503
Article type
Minireview

Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

M. M. Musa, F. Hollmann and F. G. Mutti, Catal. Sci. Technol., 2019, 9, 5487
DOI: 10.1039/C9CY01539F

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