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Issue 20, 2019
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Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

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Abstract

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.

Graphical abstract: Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

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Publication details

The article was received on 01 Aug 2019, accepted on 30 Aug 2019 and first published on 03 Sep 2019


Article type: Minireview
DOI: 10.1039/C9CY01539F
Catal. Sci. Technol., 2019,9, 5487-5503
  • Open access: Creative Commons BY license
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    Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

    M. M. Musa, F. Hollmann and F. G. Mutti, Catal. Sci. Technol., 2019, 9, 5487
    DOI: 10.1039/C9CY01539F

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