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Issue 20, 2019
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Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

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Abstract

We report the preparation of symmetrical stilbene derivatives in a two-step one-pot cascade reaction based on enzymatic decarboxylation of cinnamic acid followed by olefin cross metathesis. Embedment of the metathesis catalyst in a protein scaffold enabled the cascade reaction to symmetric stilbenes and furthermore very efficient removal of metal impurities (<1 ppm in product fraction).

Graphical abstract: Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

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Publication details

The article was received on 18 Jul 2019, accepted on 12 Sep 2019 and first published on 18 Sep 2019


Article type: Communication
DOI: 10.1039/C9CY01412H
Catal. Sci. Technol., 2019,9, 5572-5576

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    Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

    M. A. S. Mertens, D. F. Sauer, U. Markel, J. Schiffels, J. Okuda and U. Schwaneberg, Catal. Sci. Technol., 2019, 9, 5572
    DOI: 10.1039/C9CY01412H

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