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Hyperconjugation promoted by hydrogen bondings between His98/His241 and carboxyl group contributes to tyrosine decarboxylase catalysis

Abstract

The utilitiy of the σ→π* hyperconjugation in pyridoxal 5'-phosphate (PLP)-dependent tyrosine decarboxylase (TyDC) is demonstrated here for the first time. His98 and His241 form hydrogen bonds with the carboxyl group of the external aldimine and contribute to the hyperconjugation of TyDC from Lactobacillus brevis. The dihedral angle of C-Cα-NSB-C4′ in the PLP-substrate covalent complex was found to be vital to the decarboxylation efficiency of TyDC.

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Publication details

The article was received on 29 Jun 2019, accepted on 07 Oct 2019 and first published on 08 Oct 2019


Article type: Communication
DOI: 10.1039/C9CY01290G
Catal. Sci. Technol., 2019, Accepted Manuscript

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    Hyperconjugation promoted by hydrogen bondings between His98/His241 and carboxyl group contributes to tyrosine decarboxylase catalysis

    J. Ni, G. Xu, W. Dai, Y. Zhao and Y. Ni, Catal. Sci. Technol., 2019, Accepted Manuscript , DOI: 10.1039/C9CY01290G

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