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Issue 4, 2019
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Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

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Abstract

A one-pot cascade reaction sequence to obtain 1,2-diarylethanes from styrenes was developed. The cascade reaction comprises an olefin cross metathesis and a hydrogenation step with two biohybrid catalysts. One biohybrid catalyst is based on the engineered transmembrane protein FhuA harboring a Grubbs–Hoveyda-type ruthenium carbene complex and the other one harbors a rhodium(I) complex. Both active sites are covalently anchored via a modified N-heterocyclic carbene (NHC).

Graphical abstract: Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

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Publication details

The article was received on 29 Oct 2018, accepted on 11 Jan 2019 and first published on 14 Jan 2019


Article type: Communication
DOI: 10.1039/C8CY02236D
Citation: Catal. Sci. Technol., 2019,9, 942-946

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    Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

    D. F. Sauer, Y. Qu, M. A. S. Mertens, J. Schiffels, T. Polen, U. Schwaneberg and J. Okuda, Catal. Sci. Technol., 2019, 9, 942
    DOI: 10.1039/C8CY02236D

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