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Issue 13, 2019
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New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

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Abstract

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential “new keys for old locks” which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.

Graphical abstract: New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

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Article information


Submitted
14 Mar 2019
First published
19 Jun 2019

This article is Open Access

Chem. Soc. Rev., 2019,48, 3497-3512
Article type
Tutorial Review

New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

P. Stockmann, M. Gozzi, R. Kuhnert, M. B. Sárosi and E. Hey-Hawkins, Chem. Soc. Rev., 2019, 48, 3497
DOI: 10.1039/C9CS00197B

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