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Issue 15, 2019
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Functional synthetic probes for selective targeting and multi-analyte detection and imaging

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Abstract

In contrast to the classical design of a probe with one binding site to target one specific analyte, probes with multiple interaction sites or, alternatively, with single sites promoting tandem reactions to target one or multiple analytes, have been developed. They have been used in addressing the inherent challenges of selective targeting in the presence of structurally similar compounds and in complex matrices, as well as the visualization of the in vivo interaction or crosstalk between the analytes. Examples of analytes include reactive sulfur species, reactive oxygen species, nucleotides and enzymes. This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes. The vision is to promote the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes.

Graphical abstract: Functional synthetic probes for selective targeting and multi-analyte detection and imaging

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Publication details

The article was received on 02 Apr 2019 and first published on 17 Jun 2019


Article type: Review Article
DOI: 10.1039/C8CS01006D
Chem. Soc. Rev., 2019,48, 4155-4177

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    Functional synthetic probes for selective targeting and multi-analyte detection and imaging

    Y. Yue, F. Huo, F. Cheng, X. Zhu, T. Mafireyi, R. M. Strongin and C. Yin, Chem. Soc. Rev., 2019, 48, 4155
    DOI: 10.1039/C8CS01006D

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