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Issue 17, 2019

Catalytic cascade reactions by radical relay

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Abstract

Radical cascade reactions are an attractive tool for the rapid construction of complex molecular architectures. Although a large number of powerful radical cascades have been developed, stoichiometric amounts of reagents and/or additives are often required to mediate these processes. Radical relay strategies, in which radical character is recycled, require only a catalytic amount of reagent and are particularly attractive as they promise cascades that are high in atom economy. This tutorial review highlights recent advances in this rapidly developing area by setting out and dissecting the reaction designs underpinning state-of-the-art processes involving radical relays. Advances in the field of radical relay cascades will open the door to more efficient synthesis with far-reaching benefits for the makers and end-users of complex molecules.

Graphical abstract: Catalytic cascade reactions by radical relay

Article information


Submitted
02 May 2019
First published
12 Jul 2019

Chem. Soc. Rev., 2019,48, 4626-4638
Article type
Tutorial Review

Catalytic cascade reactions by radical relay

H. Huang, M. H. Garduño-Castro, C. Morrill and D. J. Procter, Chem. Soc. Rev., 2019, 48, 4626 DOI: 10.1039/C8CS00947C

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