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Catalytic cascade reactions by radical relay

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Abstract

Radical cascade reactions are an attractive tool for the rapid construction of complex molecular architectures. Although a large number of powerful radical cascades have been developed, stoichiometric amounts of reagents and/or additives are often required to mediate these processes. Radical relay strategies, in which radical character is recycled, require only a catalytic amount of reagent and are particularly attractive as they promise cascades that are high in atom economy. This tutorial review highlights recent advances in this rapidly developing area by setting out and dissecting the reaction designs underpinning state-of-the-art processes involving radical relays. Advances in the field of radical relay cascades will open the door to more efficient synthesis with far-reaching benefits for the makers and end-users of complex molecules.

Graphical abstract: Catalytic cascade reactions by radical relay

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Publication details

The article was received on 02 May 2019 and first published on 12 Jul 2019


Article type: Tutorial Review
DOI: 10.1039/C8CS00947C
Chem. Soc. Rev., 2019, Advance Article

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    Catalytic cascade reactions by radical relay

    H. Huang, M. H. Garduño-Castro, C. Morrill and D. J. Procter, Chem. Soc. Rev., 2019, Advance Article , DOI: 10.1039/C8CS00947C

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