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Biaryl synthesis with arenediazonium salts: cross-coupling, CH-arylation and annulation reactions

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Abstract

The rich legacy of arenediazonium salts in the synthesis of unsymmetrical biaryls, built around the seminal works of Pschorr, Gomberg and Bachmann more than a century ago, continues to make important contributions at various evolutionary stages of modern biaryl synthesis. Based on in-depth mechanistic analysis and design of novel pathways and reaction conditions, the scope of biaryl synthesis with arenediazonium salts has enormously expanded in recent years through applications of transition metal/photoredox-catalysed cross-coupling, thermal/photosensitized radical chain CH-arylation of (hetero)arenes and arylative radical annulation reactions with alkynes. These recent developments have provided facile synthetic access to a wide variety of unsymmetrical biaryls of pharmaceutical, agrochemical and optoelectronic importance with green scale-up options and created opportunities for late-stage modification of peptides, nucleosides, carbon nanotubes and electrodes, the details of which are captured in this review.

Graphical abstract: Biaryl synthesis with arenediazonium salts: cross-coupling, CH-arylation and annulation reactions

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Publication details

The article was received on 11 Aug 2018 and first published on 04 Jan 2019


Article type: Review Article
DOI: 10.1039/C8CS00453F
Citation: Chem. Soc. Rev., 2019, Advance Article
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    Biaryl synthesis with arenediazonium salts: cross-coupling, CH-arylation and annulation reactions

    F. Felpin and S. Sengupta, Chem. Soc. Rev., 2019, Advance Article , DOI: 10.1039/C8CS00453F

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