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Issue 4, 2019
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Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

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Abstract

Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent years, “click and release” approaches have shown great promise in the design of prodrugs because of their bioorthogonality and controlled bond-cleavage, which help ensure prodrug stability during circulation and ready cleavage at the desired site of action. This review highlights recent developments of this research field and discusses issues yet to be addressed.

Graphical abstract: Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

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Publication details

The article was received on 06 Jun 2018 and first published on 06 Feb 2019


Article type: Review Article
DOI: 10.1039/C8CS00395E
Citation: Chem. Soc. Rev., 2019,48, 1077-1094

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    Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

    X. Ji, Z. Pan, B. Yu, L. K. De La Cruz, Y. Zheng, B. Ke and B. Wang, Chem. Soc. Rev., 2019, 48, 1077
    DOI: 10.1039/C8CS00395E

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