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Barcoded point-of-care bioassays

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Abstract

Barcode technology can deliver batched information for patient healthcare. For clinical examinations, barcodes serve as reporters for labeling multiple targets, and meanwhile, facilitate improved sensitivity and specificity, thus enabling barcode as a promising alternative to traditional labels for biomarker identification and signal amplification. However, faced with the stringent claims of point-of-care (POC) bioassays, efforts are needed to advance current technologies toward rapidity, robustness, affordability, and user-friendliness. In the past decades, chemists have succeeded in delicate fabrication of the barcode libraries for encoding. Nevertheless, the decoding technologies remain poorly discussed, especially simplified decoding strategies for POC bioassays. Recent emergence of portable cartridges and miniaturized signal-recording devices has brought a promise to merge barcodes-assisted bioassay with POC testing (POCT). This review provides a comprehensive summary on barcode encoding and decoding, with emphasis on their potential use in POCT, facilitated by improved manufacturing and portable devices. Future directions of barcoded bioassays for POCT and current challenges are also presented. We anticipate that this review will be beneficial to promoting barcodes toward broad applications.

Graphical abstract: Barcoded point-of-care bioassays

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Publication details

The article was received on 09 Aug 2018 and first published on 19 Dec 2018


Article type: Review Article
DOI: 10.1039/C8CS00303C
Citation: Chem. Soc. Rev., 2019, Advance Article
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    Barcoded point-of-care bioassays

    M. Yang, Y. Liu and X. Jiang, Chem. Soc. Rev., 2019, Advance Article , DOI: 10.1039/C8CS00303C

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