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Recent advances in nucleophile-triggered CO2-incorporated cyclization leading to heterocycles

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Abstract

Carbon dioxide (CO2) has emerged as a sustainable, feasible, abundant one-carbon synthon and displays great potential in the synthesis of heterocycles such as lactones, lactams, and 2-oxazolidinones, which are privileged motifs in pharmaceutical chemistry demonstrating bioactivities. Although the fixation of CO2 is restricted due to its thermodynamic stability and kinetic inertness, multiple breakthroughs have been realized in annulation chemistry. This review concentrates on the advances made in the last five years in CO2-incorporated cyclization triggered by N-, O-, and C-nucleophiles. Three transformation modes of CO2 including carboxylative cyclization, carbonylative cyclization, and reductive cyclization have been summarized. Moreover, typical mechanisms and significant applications of these reactions are also described.

Graphical abstract: Recent advances in nucleophile-triggered CO2-incorporated cyclization leading to heterocycles

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Publication details

The article was received on 10 Apr 2018 and first published on 27 Nov 2018


Article type: Review Article
DOI: 10.1039/C8CS00281A
Citation: Chem. Soc. Rev., 2019, Advance Article
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    Recent advances in nucleophile-triggered CO2-incorporated cyclization leading to heterocycles

    S. Wang and C. Xi, Chem. Soc. Rev., 2019, Advance Article , DOI: 10.1039/C8CS00281A

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