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Issue 2, 2019
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Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

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Abstract

Bacterial-infections are mostly due to bacteria in an adhering, biofilm-mode of growth and not due to planktonically growing, suspended-bacteria. Biofilm-bacteria are much more recalcitrant to conventional antimicrobials than planktonic-bacteria due to (1) emergence of new properties of biofilm-bacteria that cannot be predicted on the basis of planktonic properties, (2) low penetration and accumulation of antimicrobials in a biofilm, (3) disabling of antimicrobials due to acidic and anaerobic conditions prevailing in a biofilm, and (4) enzymatic modification or inactivation of antimicrobials by biofilm inhabitants. In recent years, new nanotechnology-based antimicrobials have been designed to kill planktonic, antibiotic-resistant bacteria, but additional requirements rather than the mere killing of suspended bacteria must be met to combat biofilm-infections. The requirements and merits of nanotechnology-based antimicrobials for the control of biofilm-infection form the focus of this Tutorial Review.

Graphical abstract: Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

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Publication details

The article was received on 19 Jul 2018 and first published on 02 Jan 2019


Article type: Tutorial Review
DOI: 10.1039/C7CS00807D
Citation: Chem. Soc. Rev., 2019,48, 428-446

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    Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

    Y. Liu, L. Shi, L. Su, H. C. van der Mei, P. C. Jutte, Y. Ren and H. J. Busscher, Chem. Soc. Rev., 2019, 48, 428
    DOI: 10.1039/C7CS00807D

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