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The reduction potential of the slipped GC base pair in one-electron oxidized duplex DNA

Abstract

Redox equilibrium between the low potential aniline cation radical and the guanyl radical in the GC base pair of duplex DNA has been established using pulse radiolysis. We relate the finding of a radical one-electron reduction potential, E0’, of 1.01 ± 0.03 V to the perturbation of the GC base pair to accommodate the neutral guanyl radical in an energetically more stable ‘slipped’ structure. The proposed radical pathway is supported by DFT calculations.

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Publication details

The article was received on 11 Oct 2019, accepted on 02 Dec 2019 and first published on 02 Dec 2019


Article type: Paper
DOI: 10.1039/C9CP05544D
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript

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    The reduction potential of the slipped GC base pair in one-electron oxidized duplex DNA

    R. Anderson, S. S. Shinde, A. Maroz and J. Reynisson, Phys. Chem. Chem. Phys., 2019, Accepted Manuscript , DOI: 10.1039/C9CP05544D

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