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The reduction potential of the slipped GC base pair in one-electron oxidized duplex DNA

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Abstract

Redox equilibrium between the low potential aniline radical cation and the guanine in the GC base pair of duplex DNA has been established using pulse radiolysis. We relate the measurement of a radical one-electron reduction potential, E0′, of 1.01 ± 0.03 V to the perturbation of the GC base pair to accommodate the neutral guanyl radical in an energetically more stable ‘slipped’ structure. The formation of the ‘slipped’ structure is exothermic by −11.4 kcal mol−1 as calculated by DFT, which is inline with our experimental results.

Graphical abstract: The reduction potential of the slipped GC base pair in one-electron oxidized duplex DNA

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Publication details

The article was received on 11 Oct 2019, accepted on 02 Dec 2019 and first published on 02 Dec 2019


Article type: Paper
DOI: 10.1039/C9CP05544D
Phys. Chem. Chem. Phys., 2020, Advance Article

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    The reduction potential of the slipped GC base pair in one-electron oxidized duplex DNA

    R. F. Anderson, S. S. Shinde, A. Maroz and J. Reynisson, Phys. Chem. Chem. Phys., 2020, Advance Article , DOI: 10.1039/C9CP05544D

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