Issue 41, 2019

Production of highly concentrated and hyperpolarized metabolites within seconds in high and low magnetic fields

Abstract

Hyperpolarized metabolites are very attractive contrast agents for in vivo magnetic resonance imaging studies enabling early diagnosis of cancer, for example. Real-time production of concentrated solutions of metabolites is a desired goal that will enable new applications such as the continuous investigation of metabolic changes. To this end, we are introducing two NMR experiments that allow us to deliver high levels of polarization at high concentrations (50 mM) of an acetate precursor (55% 13C polarization) and acetate (17% 13C polarization) utilizing 83% para-state enriched hydrogen within seconds at high magnetic field (7 T). Furthermore, we have translated these experiments to a portable low-field spectrometer with a permanent magnet operating at 1 T. The presented developments pave the way for a rapid and affordable production of hyperpolarized metabolites that can be implemented in e.g. metabolomics labs and for medical diagnosis.

Graphical abstract: Production of highly concentrated and hyperpolarized metabolites within seconds in high and low magnetic fields

Supplementary files

Article information

Article type
Paper
Submitted
23 Sep 2019
Accepted
01 Oct 2019
First published
08 Oct 2019
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2019,21, 22849-22856

Production of highly concentrated and hyperpolarized metabolites within seconds in high and low magnetic fields

S. Korchak, M. Emondts, S. Mamone, B. Blümich and S. Glöggler, Phys. Chem. Chem. Phys., 2019, 21, 22849 DOI: 10.1039/C9CP05227E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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