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Modulating Intramolecular Chalcogen Bonds in Aromatic (thio)(seleno)phene-Based derivatives

Abstract

Intramolecular interactions have been proven to be the key to conformational control in drug-design. While chalcogen interactions have been shown to be present in certain ligands of the GK-GKRP target protein, in the present study, intramolecular chalcogen interactions through selenium are found to be even more promising since they form stronger interactions. Also, the flexibility/rigidity of the carbon backbone of the corresponding ligands is crucial in the conformational stability.

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Publication details

The article was received on 30 Jun 2019, accepted on 09 Oct 2019 and first published on 09 Oct 2019


Article type: Paper
DOI: 10.1039/C9CP03694F
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript

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    Modulating Intramolecular Chalcogen Bonds in Aromatic (thio)(seleno)phene-Based derivatives

    C. Trujillo, I. Rozas, J. Elguero, I. Alkorta and G. Sánchez-Sanz, Phys. Chem. Chem. Phys., 2019, Accepted Manuscript , DOI: 10.1039/C9CP03694F

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