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Issue 42, 2019
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Modulating intramolecular chalcogen bonds in aromatic (thio)(seleno)phene-based derivatives

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Abstract

Intramolecular interactions have been proven to be the key to conformational control in drug-design. While chalcogen interactions have been shown to be present in certain ligands of the GK–GKRP target protein, in the present study, intramolecular chalcogen interactions through selenium are found to be even more promising since they form stronger interactions. Also, the flexibility/rigidity of the carbon backbone of the corresponding ligands is crucial in the conformational stability.

Graphical abstract: Modulating intramolecular chalcogen bonds in aromatic (thio)(seleno)phene-based derivatives

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Supplementary files

Article information


Submitted
30 Jun 2019
Accepted
09 Oct 2019
First published
09 Oct 2019

Phys. Chem. Chem. Phys., 2019,21, 23645-23650
Article type
Paper

Modulating intramolecular chalcogen bonds in aromatic (thio)(seleno)phene-based derivatives

C. Trujillo, I. Rozas, J. Elguero, I. Alkorta and G. Sánchez-Sanz, Phys. Chem. Chem. Phys., 2019, 21, 23645
DOI: 10.1039/C9CP03694F

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