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Issue 31, 2019
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Influence of polar co-solutes and salt on the hydration of lipid membranes

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Abstract

The influence of the co-solutes TMAO, urea, and NaCl on the hydration repulsion between lipid membranes is investigated in a combined experimental/simulation approach. Pressure–hydration curves obtained via sorption experiments reveal that the repulsion significantly increases when the membranes are loaded with co-solutes, most strongly for TMAO. As a result, the co-solutes retain additional water molecules and therefore provide membranes with a fluid and more physiological environment. The experimental data are quantitatively reproduced in complementary solvent-explicit atomistic molecular dynamics simulations, which yield the chemical potential of water. Simulation analysis reveals that the additional repulsion arises from the osmotic pressure generated by the co-solutes, an effect which is maximal for TMAO, due to its unfavorable interactions with the lipid headgroup layer and its extraordinarily high osmotic coefficient.

Graphical abstract: Influence of polar co-solutes and salt on the hydration of lipid membranes

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Article information


Submitted
08 Apr 2019
Accepted
15 Jul 2019
First published
18 Jul 2019

This article is Open Access

Phys. Chem. Chem. Phys., 2019,21, 16989-17000
Article type
Paper

Influence of polar co-solutes and salt on the hydration of lipid membranes

A. Wolde-Kidan, Q. D. Pham, A. Schlaich, P. Loche, E. Sparr, R. R. Netz and E. Schneck, Phys. Chem. Chem. Phys., 2019, 21, 16989
DOI: 10.1039/C9CP01953G

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