Issue 22, 2019

Understanding the affinity of bis-exTTF macrocyclic receptors towards fullerene recognition

Abstract

A new series of fullerene receptors based on exTTF macrocycles with alkyl ether chains of increasing length is reported. The novel macrocyclic receptors are able to favourably interact with fullerene C60 through a synergistic combination of π–π, CH⋯π and n⋯π noncovalent interactions. We identify that the highest affinity towards C60 recognition is achieved for the host with the tightest fit; that is, the smallest receptor with a cavity large enough to host the buckyball inside (log Ka = 5.2 in chlorobenzene at 298 K). However, besides this expected observation, theoretical calculations evidence that the most stable self-assembling configuration corresponds for all the receptors to an outside-ring binding mode, in which the C60 guest is out of the cavity of the receptor. The higher stability of this configuration results from the smaller deformation energy it implies for the receptor, and allows to explain the experimental trends in the association constants.

Graphical abstract: Understanding the affinity of bis-exTTF macrocyclic receptors towards fullerene recognition

Supplementary files

Article information

Article type
Paper
Submitted
28 Mar 2019
Accepted
18 May 2019
First published
20 May 2019

Phys. Chem. Chem. Phys., 2019,21, 11670-11675

Understanding the affinity of bis-exTTF macrocyclic receptors towards fullerene recognition

J. Calbo, A. de Juan, J. Aragó, J. Villalva, N. Martín, E. M. Pérez and E. Ortí, Phys. Chem. Chem. Phys., 2019, 21, 11670 DOI: 10.1039/C9CP01735F

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