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Redox-Probe-Free Scanning Electrochemical Microscopy Combined with Fast Fourier Transform Electrochemical Impedance Spectroscopy

Abstract

Scanning electrochemical microscopy (SECM) hybridized with fast Fourier transform based electrochemical impedance spectroscopy (FFT-EIS) seems to be a powerful variation of scanning electrochemical impedance microscopy (SEIM) where both state-of-the-art techniques are combined (FFT-SEIM), which in short perspective can be used for the investigation and treatment of tissues at single cell level. However, in the most EIS-based experiments harmful redox mediators are applied, which are disordering function of living cells and tissues. Therefore, the development of redox-probe-free FFT-SEIM is still very important challenge of electrochemistry. For this reason, in this research we have demonstrated a redox-probe-free evaluation of conducting and non-conducting surfaces by combining scanning electrochemical microscopy with FFT-EIS. It was demonstrated that by fast Fourier transform FFT-EIS technique EIS spectra could be registered much faster, compared to experiments performed using conventional EIS equipment. Ultramicroelectrode (UME) was used as scanning electrode to assure high spatial resolution. We have performed FFT-SEIM measurements in redox-probe-free mode (without any additional redox probes) and have investigated several surfaces of different conductivities. The FFT-EIS equipment and software enables to avoid the influence of possible formation of hydrogen bubbles on the UME. This research opens new avenue for the application of FFT-SEIM in the investigation of samples, which are unstable and very sensitive towards redox mediators (e.g. tissues and/or living cells).

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Publication details

The article was received on 11 Jan 2019, accepted on 04 Apr 2019 and first published on 05 Apr 2019


Article type: Paper
DOI: 10.1039/C9CP00187E
Citation: Phys. Chem. Chem. Phys., 2019, Accepted Manuscript

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    Redox-Probe-Free Scanning Electrochemical Microscopy Combined with Fast Fourier Transform Electrochemical Impedance Spectroscopy

    A. Valiuniene, J. Petroniene, I. Morkvenaite-Vilkonciene, G. Popkirov, A. Ramanaviciene and A. Ramanavicius, Phys. Chem. Chem. Phys., 2019, Accepted Manuscript , DOI: 10.1039/C9CP00187E

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