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Probing the role of dispersion energy on structural transformation of double-stranded xylo- and ribo- nucleic acids

Abstract

The structural transformation of double-stranded octameric xyloNA and RNA were probed by modulating the dispersion energy. For the RNA the increase and the decrease in dispersion energy leads to over-winind and unwinidng of the helix. These structural transformations resembles the features observed due to action of the enzymes topoisomerases and helicases, respectively. On the other hand, increase in dispersion energy has minimal effect on the structural transformation of double-strand xyloNA, whilst decrease in dispersion energy results in the structural transformation which happens due to the action of helicases. The unresponsive behaviour of xyloNA to increase in the dispersion energy is attributed to the presence of Lp···π interaction between the oxygen atom of the xylose sugar and the adjacent nucleobase.

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Publication details

The article was received on 10 Oct 2018, accepted on 10 Jan 2019 and first published on 11 Jan 2019


Article type: Paper
DOI: 10.1039/C8CP06305B
Citation: Phys. Chem. Chem. Phys., 2019, Accepted Manuscript
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    Probing the role of dispersion energy on structural transformation of double-stranded xylo- and ribo- nucleic acids

    A. Kumar and N. G. Patwari, Phys. Chem. Chem. Phys., 2019, Accepted Manuscript , DOI: 10.1039/C8CP06305B

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