Piroxicam–clonixin drug–drug cocrystal solvates with enhanced hydration stability

Abstract

Cocrystallisation of two non-steroidal anti-inflammatory drugs, piroxicam and clonixin, yielded eight drug–drug cocrystal solvates. Solvents having a moderate polarity are essential for the formation and stabilization of these crystalline complexes. The pharmaceutically acceptable ethyl acetate solvate demonstrated superior physical stability against hydration.