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Issue 13, 2019
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Polymorphism in p-aminobenzoic acid

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Abstract

We review the polymorphism of p-aminobenzoic acid (pABA), a model drug compound whose crystallisation and polymorphic behaviour has been extensively studied in recent years. Beyond the well-known and characterised α and β forms, pABA also crystallises as a γ polymorph, which is structurally similar to the α form. In addition we also compare the newly reported δ form, obtained by high pressure crystallisation and through compression of the α-form. A structural analysis and comparison of all of the forms is presented, the conditions by which each of them is obtained summarised. Crystal structure prediction calculations have also been carried out in order to probe the solid form energy landscape of this compound. The overall picture of the polymorphism of pABA, reveals, surprisingly, the rarity of the β form.

Graphical abstract: Polymorphism in p-aminobenzoic acid

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Publication details

The article was received on 05 Nov 2018, accepted on 12 Jan 2019 and first published on 22 Jan 2019


Article type: Highlight
DOI: 10.1039/C8CE01890A
CrystEngComm, 2019,21, 2034-2042

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    Polymorphism in p-aminobenzoic acid

    A. J. Cruz-Cabeza, R. J. Davey, I. D. H. Oswald, M. R. Ward and I. J. Sugden, CrystEngComm, 2019, 21, 2034
    DOI: 10.1039/C8CE01890A

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