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Issue 3, 2019
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A novel homochiral metal–organic framework with an expanded open cage based on (R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl: synthesis, X-ray structure and efficient HPLC enantiomer separation

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Abstract

A new homochiral metal–organic framework (MOF) with an expanded open cage based on the (R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl ligand was synthesized and utilized as a novel chiral stationary phase for high-performance liquid chromatography. Twelve racemates including sec-alcohols, sulfoxides, epoxides, lactone, 1,3-dioxolan-2-one, and oxazolidinone were used as analytes for evaluating the separation properties of the chiral-MOF-packed column. Experimentally, the homochiral MOF offered good molecular recognition ability, which suggests good prospects for the application of chiral MOFs as stationary phases for enantioseparation.

Graphical abstract: A novel homochiral metal–organic framework with an expanded open cage based on (R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl: synthesis, X-ray structure and efficient HPLC enantiomer separation

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Publication details

The article was received on 19 Oct 2018, accepted on 02 Dec 2018 and first published on 03 Dec 2018


Article type: Paper
DOI: 10.1039/C8CE01791C
Citation: CrystEngComm, 2019,21, 487-493
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    A novel homochiral metal–organic framework with an expanded open cage based on (R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl: synthesis, X-ray structure and efficient HPLC enantiomer separation

    K. Tanaka, T. Kawakita, M. Morawiak and Z. Urbanczyk-Lipkowska, CrystEngComm, 2019, 21, 487
    DOI: 10.1039/C8CE01791C

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