Issue 2, 2020
From the journal:

Chemical Communications

Ruthenium-catalyzed meta-C–H bond alkylation of aryl 2-pyridyl ketones†

Gang Li, ORCID logo *ab   Chunqi Jia,‡c   Xiaofeng Cai,‡ab   Lei Zhong,ab   Lei Zouab  and  Xiuling Cui*c  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, P. R. China

b Henan Province Key Laboratory of New Optoelectronic Functional Materials, Anyang Normal University, Anyang 455002, P. R. China

c Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China
E-mail: cuixl@hqu.edu.cn

Abstract

The first example of meta-selective CAr–H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone skeletons, which are found in various functional molecules.

Graphical abstract: Ruthenium-catalyzed meta-C–H bond alkylation of aryl 2-pyridyl ketones

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Article information

DOI
https://doi.org/10.1039/C9CC08624B
Article type
Communication
Submitted
05 Nov 2019
Accepted
28 Nov 2019
First published
29 Nov 2019

Chem. Commun., 2020,56, 293-296

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Ruthenium-catalyzed meta-C–H bond alkylation of aryl 2-pyridyl ketones

G. Li, C. Jia, X. Cai, L. Zhong, L. Zou and X. Cui, Chem. Commun., 2020, 56, 293 DOI: 10.1039/C9CC08624B

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