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Issue 98, 2019
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A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

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Abstract

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.

Graphical abstract: A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

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Publication details

The article was received on 31 Oct 2019, accepted on 08 Nov 2019 and first published on 22 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08518A
Chem. Commun., 2019,55, 14777-14780

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    A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

    F. Nardelli, M. Ghitti, G. Quilici, A. Gori, Q. Luo, A. Berardi, A. Sacchi, M. Monieri, G. Bergamaschi, W. Bermel, F. Chen, A. Corti, F. Curnis and G. Musco, Chem. Commun., 2019, 55, 14777
    DOI: 10.1039/C9CC08518A

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