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Issue 98, 2019
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Plasticity in designing PROTACs for selective and potent degradation of HDAC6

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Abstract

HDAC6 (histone deacetylase 6) catalyses the deacetylation of non-histone substrates, and plays important roles in cell migration, protein degradation and other cellular processes. Here we report that CRBN-recruiting PROTAC NH2, which introduces pomalidomide at the benzene ring of Nex A, reaches comparable degradation efficiency of HDAC6 compared to aliphatic-chain-introducing PROTAC NP8.

Graphical abstract: Plasticity in designing PROTACs for selective and potent degradation of HDAC6

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Publication details

The article was received on 31 Oct 2019, accepted on 08 Nov 2019 and first published on 19 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08509B
Chem. Commun., 2019,55, 14848-14851

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    Plasticity in designing PROTACs for selective and potent degradation of HDAC6

    H. Yang, W. Lv, M. He, H. Deng, H. Li, W. Wu and Y. Rao, Chem. Commun., 2019, 55, 14848
    DOI: 10.1039/C9CC08509B

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